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In 1845, a Scottish doctor, James Esdale, opened a hospital in Calcutta and began a famous serious of operations with no pain and almost no deaths. His practice was made up of rajahs with 100 prominent witnesses. In India, so many had been afraid of operations, they had lived with tumors sometimes as large as their bodies (up to 80 pounds). By the time he left, he had performed over 2000 operations.
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